Cancer Genomic Resources

Cancer Genomic Resources

This page provide information about how and when to use the resources found in the CGC Geneticist Toolkit.

Clinical/Pathology Background

WHO Blue Books - can purchase books (one per organ system) or pay annual fee for online subscription (includes access to all current books)

The World Health Organization classification of established somatic/acquired disorders, ordered by organ systems and pathology nomenclature. Each disorder page can include a pathology definition, etiology, clinical features, immunophenotype, genetic profile including cytogenetic abnormalities and oncogenes, genetic susceptibility, prognosis and predictive factors.
- Annual subscription to WHO Classification of Tumours Online – IARC E-Bookshop
- IARC Publications Website - WHO Classification of Tumours

National Comprehensive Cancer Network (NCCN) Guidelines - create a free account (need to provide e-mail address)

The NCCN website provides updated oncology clinical practice guidelines for clinicians which can include diagnostic, prognostic, therapeutic, and cytogenetics risk categories (if available).
Click on Guidelines Treatment by Cancer Type select tumor type.

Evaluating significance of chromosome abnormalities

Collaborative wiki style pages for chromosome and genomic abnormalities structured based on current WHO classifications.
Disease pages provide information about recurrent genetic abnormalities seen in that tumor type and clinical significance.
Includes Recurrent Loci Tables from CGC publications showing clinically significant abnormalities in different tumor types
This page provides more details about the site, how to search, and how to volunteer to contribute content.

A database that provides information about common cytogenetics abnormalities - an overview of the disease pathology, possible variants, genes and proteins involved, treatments, a summary of the alteration which includes representative pictures at different banding resolutions, and references.
For examples of how to search the Atlas, click here.

This freely available online database relates cytogenetic abnormalities to tumor type, based on data from the literature. This database is supported by the National Cancer Institute, the Swedish Cancer Society and the Swedish Childhood Cancer Foundation, and is updated four times a year. For more information about the database, click here.
For examples of how to search the Mitelman database, click here.

Gene Translocations and Rearrangements